VectraCor has received the support of Key Opinion Leaders (KOL) in the cardiology and acute care fields, and more specifically of the CEB® and derived ECG technology. The Company sought out physicians and researchers to conduct clinical studies and use the VectraplexECG System in their facilities. Some of the participating institutions and the studies that were conducted are outlined below.

Read our clinical validation summary for a quick rundown.

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Published study comparing the CEB® to high sensitivity troponin blood test/cardiac serum markers. Presented at ACC 2014 in San Francisco, CA. Published in Critical Pathways in Cardiology - Volume 13, Number 1, March 2014

Conclusions: In conclusion, in patients in ED evaluated for acute myocardial injury, increasing values of HsTnI were associated with increasing values of the CEB®, suggesting that myocardial injury is associated with acute changes in the CEB® in the population of patients with high pretest probability of acute myocardial injury.

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Prospective study in the Cardiac Cath Lab – Study presented at the American College of Cardiology Conference (ACC) in Washington, DC in March 2017

Conclusions: The CEB® shows a positive response to balloon and stent inflation during PCI with a strong correlation. The CEB® appears to show a stronger response to balloon inflation in larger arteries, cases involving infarction, and in greater severity stenosis. The CEB® may be an efficient and timely means of detecting myocardial ischemia in patients who are being monitored in acute care settings.

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University of Basel Leading Research Facility Worldwide on Cardiac Serum Markers - Cardiac Electrical Biomarker, a Novel Marker Diagnosing Myocardial Injury in Patients With Symptoms Suggestive for NSTEMI. Presented at the AHA in November 2017 in Orlando, FL (Published in Circulation. 2017;136:A13562)

Conclusion: The CEB®, an ECG marker of myocardial injury, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI.

University of Basel Leading Research Facility Worldwide on Cardiac Serum Markers/High Sensitivity Troponin (Dr. Mueller/Dr. Reichlin).  Published and presented at The European Society of Cardiology Conference in Rome - September 2016.  Abstract has been published, and the full manuscript is done and being submitted to a leading journal.

Conclusion: The CEB®, a novel ECG marker indicating myocardial injury, significantly improves the diagnostic accuracy of the ECG for the diagnosis of AMI.

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Atlantic Health System/Summit Medical Group

Published 7 studies/abstracts from Dr. Schreck and Dr. Fishberg - Dr. Schreck has published over 40 abstracts over the past 30 years. Presented abstracts at numerous conferences (ACC, ACEP, SCCM, ISCE and others)

 

 

  • Schreck DM, et al:  Factor analysis of normal and abnormal ECGs.  Ann Emerg. Med. (Abstract) 1990; 19:1226.
  • Schreck DM, et al: The synthesis of normal and infarction electrocardiograms from principal vectors by factor analysis.  Ann Emerg. Med. (Abstract) 1992; 21-462
  • Schreck DM, et al:  Factor analysis of the electrocardiogram and vectorcardiogram.  Crit. Care Med (Abstract) 1994; January (Supp).
  • Schreck DM, et al:  Mathematical modeling of the electrocardiogram and vectorcardiogram.  Ann Emerg. Med. (Abstract) 1994; March.
  • Schreck DM, et al:  Fractal dynamics of the electrocardiogram.  Academic Emerg. Med. (Abstract) 1994; April
  • Schreck DM, et al:  Factor analysis of the standard electrocardiogram.  Acad Emerg Med  (Abstract) May 1996.
  • Schreck DM, et al: Fractal dynamics of normal and infarction electrocardiograms:  A computer predictive model.  Ann Emerg Med (Abstract) 1997; 30:430-431.
  • Schreck DM, et al:  Prediction of the electrocardiogram using iterative key set factor analysis and target factor analysis. Ann Emerg Med (Abstract) 1998; 32:S46.
  • Schreck DM, et al:  Mathematical modeling of the standard electrocardiogram using polynomial abductive network.  Ann Emerg Med (Abstract) 1998; 32:S46.
  • Schreck DM, et al: Statistical methodology: VI. Mathematical modeling of the electrocardiogram using factor analysis. Acad Emerg Med 1998; 5(9):929-934.
  • Schreck DM, et al: Prediction of the 19-lead electrocardiogram from 3 lead-vectors using factor analysis.  Ann Emerg Med (Abstract) 1999; 34:S25.
  • Schreck DM, et al: Factor analysis of the 19-lead electrocardiogram.  Crit Care Med 1999; 27(Suppl.):A31.
  • Schreck DM, et al: Prediction of the 12-lead electrocardiogram from 3 lead-vectors using factor analysis.  Ann Emerg Med (Abstract) 2000; 35:S62.
  • Schreck DM, et al: Electrocardiogram mathematical modeling using simplex optimization. Ann Emerg Med (Abstract) 2000; 36:S71
  • Schreck DM, et al:  The derivation and electrical basis of the 22-Lead electrocardiogram: a computer mathematical model. Ann Emerg Med (Abstract) Oct 2001.
  • Schreck DM, et al:  Derivation of the 12-lead electrocardiogram using abstract factor analysis and simplex optimization. Int J Bioelectromagnetism 2002; 4(2):337-338.
  • Schreck DM, et al:  On the derivation of a new cardiac marker: the electrocardiogram eigenvalues. Ann Emerg Med (Abstract) September 2002; 40(4):S70.
  • Schreck DM, et al:  The derivation of the 12_lead ECG from 3 standard leads.  Prehospital Emergency Care 2003; 7:160-161.
  • Schreck DM, et al:  A new marker for myocardial infarction: a real time computer model of measured and derived ECG eigenvalues.  Crit Care Med 2003; 30(12 suppl):A20.
  • Schreck DM, et al: Mathematical modeling of the electroencephalogram. Acad Emerg Med 2003;10:439.
  • Schreck DM, et al: Mathematical modeling of the electroencephalogram. Ann Emerg Med 2003;42:S3.
  • Schreck DM, et al: A real-time cardiac marker for acute infarction: eigenvalues of the measured and derived ECG. Ann Emerg Med 2003;42:S30.
  • Schreck DM, et al: The Derived N-Lead Electrocardiogram.  Crit Care Med 2003;  31 (12 suppl):A62
  • Schreck DM, et al: Clinical application of eigenvalue analysis and the derived electrocardiogram as a real-time marker for infarction.  J Am Coll Cardiol 2004; 43(5 suppl): 424
  • Schreck DM, et al: The eigenvalue as an electrical marker in the prediction of acute myocardial infarction in measured and derived electrocardiograms.  Computers in Cardiology 2004, Chicago, Illinois. (Proceedings) Page 46.
  • Schreck DM, et al:  The derived n-lead electrocardiogram.  Ann Emerg Med 2004; 44(4 supplement):S73-S74.
  • Schreck DM, et al:  The eigenvalue model as an electrical marker in the prediction of acute myocardial infarction in measured and derived electrocardiograms. Ann Emerg Med 2004;44(4 supplement):S124.
  • Schreck DM, et al:  The eigenvalue model as an electrical marker in the prediction of acute myocardial infarction in measured and derived electrocardiograms. Circulation 2004;110 (17 Supplement III): 668.
  • Schreck DM, et al:  Mathematical modeling of the electroencephalogram using factor analysis.  Crit Care Med 2004; 32 (12 suppl):A20
  • Schreck DM, et al:  The eigenvalues of the derived 12-lead ECG: A new cardiac electrical marker for acute myocardial infarction. Prehospital Emergency Care 2005; 9 (1): 120.
  • Schreck DM, et al: The derived ECG eigenvalues: A marker for acute infarction. Journal of Electrocardiology 2005; 38(4S):143.
  • Schreck DM:  The eigenvalues of the electrocardiogram: A new electrical cardiac marker for acute myocardial infarction. Chest 2005;128(4 Suppl): 284S.
  • Schreck DM, et al: The mathematical modeling and utility of the derived electrocardiogram.  Circulation 2005; 112(17): II-1111.
  • Schreck DM, Schreck AJ: Mathematical modeling of the derived electrocardiogram. Crit Care Med 2005; 33 (12 suppl): A57.
  • Schreck DM, et al:  Mathematical modeling of the electrocardiogram. Ann Emerg Med 2006;48(4 supplement):S29.
  • Schreck DM, et al: The derived electrocardiogram eigenvalues as a marker for acute myocardial infarction. Acad Emerg Med 2007;14(5 suppl): S73-S74.
  • Schreck DM:  Eigenvalue analysis of the 15-lead electrocardiogram. Crit Care Med 2007; 35(12 Suppl): A71